The gut microbiome is a complex ecosystem composed of different species of microorganisms that live in the digestive tract. The microbiome is the collective name for all the microbes that live in and on the human body. It’s estimated that the average person hosts about 39 trillion microorganisms, collectively known as the microbiome (1). The majority of your microbiome diversity can be traced back to your mother. The womb is typically considered a sterile environment free of microbes, but when we’re born and pass through the birth canal, we get covered in bacteria. The food we eat also has a direct impact on the microbes in our gut, and this can change depending on our diet. For example, if we switch from eating meat to being vegetarian, the bacteria in our gut will also change. These microbes are essential for maintaining good health and are involved in many metabolic processes that take place within the body.

Studies have shown that an unbalanced gut microbiome composition can lead to various diseases including obesity, diabetes, inflammatory bowel disease, and even some mental illnesses, such as depression and anxiety. An unhealthy diet or lifestyle can greatly reduce biodiversity within the gut microbiome, resulting in poor health outcomes. On the other hand, a healthy, balanced diet, consisting of proteins, healthy fats, and carbs rich in probiotics and prebiotics (fruits and vegetables) will help increase the diversity of beneficial bacteria within the gut microbiome, which can help improve overall health and prevent disease.

Recent advances in sequencing technology have enabled us to investigate how the composition of a person’s microbial communities can affect their risk for various diseases. For example, studies have shown that people with obesity have a different mix of microbes than those who are lean. Additionally, evidence suggests that certain bacterial species may be involved in metabolic processes associated with obesity and diabetes.

The gut microbiome is also involved in regulating our immune system. Studies suggest that it plays an important role in the development of autoimmune disorders such as rheumatoid arthritis and multiple sclerosis (MS). The presence of certain bacterial species has been linked to a decreased risk of developing these disorders, while other species have been linked to an increased risk.

The gut microbiome is also associated with mental health. Studies suggest that a diverse and balanced gut microbiome composition may help reduce the risk of depression, anxiety, and other mental illnesses. Additionally, research has shown that certain bacterial species are associated with improved cognition in older adults.

Every reason above is a sufficient case for taking probiotics alongside fighting Candida Overgrowth. Probiotics can help balance a person’s gut microbiome, strengthening the beneficial bacteria and discouraging Candida growth. Probiotic supplementation can also reduce inflammation in the gut, helping to prevent the adherence of Candida and other pathogenic microorganisms. Finally, probiotics are known to contain antifungal compounds which directly inhibit Candida growth. In addition to probiotics, prebiotics can be taken alongside antifungal medicines for a full-bodied approach to fighting Candida Overgrowth.

Did you know that the first probiotic strain was discovered in 1905 by Dr. Stamen Grigorov, a Bulgarian physician, and microbiologist? Although probiotic supplements are common today, this historic discovery has shaped the modern supplement industry as we now know them. He identified the strain Lactobacillus bulgaricus, which is still used today in yogurt and other fermented dairy products. Since then, the health benefits of probiotics have been studied extensively and a wide variety of different probiotic strains have been isolated, many of which can be taken as supplements.

The Benefits of Probiotic Supplements

There are multiple benefits to taking probiotics in a supplement form compared to probiotic foods

  • Convenience

Probiotic supplements are convenient and easy to take. They can be taken at any time and don’t require any meal planning or preparation. Many probiotics don’t need to be refrigerated, making them even more convenient to take with you on the go.

  • Exact dosage

It’s challenging to estimate how many probiotics you are consuming when eating foods that contain them, like yogurt or kefir. On the other hand, probiotic supplements provide a controlled dose of bacteria that can be taken each day at exact intervals to increase health benefits.

  • Selection of strains

With supplements, it’s possible to select specific strains of bacteria that are beneficial for particular health conditions. Some supplements contain a combination of helpful probiotics while others may only have one strain. Having the ability to tailor your supplement choice is very advantageous when you are trying to target a specific health condition.

  • Complimentary to probiotic foods

Probiotic foods are excellent sources of highly bioavailable probiotics, but taking supplements can provide higher doses of these beneficial bacteria. Additionally, taking a probiotic supplement in combination with probiotic foods can be a great way to boost your daily intake of beneficial bacteria.

Probiotics List

Here is the list of suggested probiotics, along with the strains and dosing:

BrandBacteria strainsCFUDosing
AlignBifidobacterium Longum1 billion1 capsule per day
Bio-K + Daily CareLactobacillus casei, Lactobacillus rhamnosus, Lactobacillus acidophilus50 billion1 capsule per day
Culturelle Pro Strength Digestive DailyLactobacillus rhamnosus12 billion1 capsule per day
Florastor DailySaccharomyces boulardii 250 mg per capsule2 capsules per day
Garden of Life Once Daily Women’s16 strains:  Lactobacillus acidophilus, Lactobacillus plantarum, Lactobacillus casei, Lactobacillus paracasei, Lactobacillus bulgaricus, Lactobacillus brevis, Lactobacillus reuteri, Lactobacillus salivarius, Lactobacillus fermentum, Lactobacillus gasseri, Lactobacillus rhamnosus, Bifidobacterium lactis, Bifidobacterium bifidum, Bifidobacterium breve, Bifidobacterium infantis, Bifidobacterium longum50 billion1 capsule per day
Jarrow Formulas Saccharomyces Boulardii + MOSSaccharomyces boulardii (an S. cerevisiae strain), Bio-MOS (Manno-oligosaccharides) derived from S. cerevisiae5 billion1 capsule per day
Nature’s Bountry Controlled Delivery Probiotic6 strains: Lactobacillus plantarum,  Lactobacillus acidophilus, Lactobacillus fermentum, Lactobacillus rhamnosus, Bifidobacterium bifidum, Bifidobacterium longum2 billion1 caplet per day
Nature’s Way Probiotic PearlsBifidobacterium longum, Lactobacillus acidophilus1 billion1 softgel per day
NOW Probiotic 10Blend of 10 strains: Lactobacillus acidophilus, Bifidobacterium lactis, Lactobacillus plantarum, Lactobacillus casei, Lactobacillus rhamnosus, Lactobacillus paracasei, Bifidobacterium breve, Streptocous thermophilus, Lactobacillus salivarius, Bifidobacterium longum25 billion 1 capsule x 1-2 times per day 
Swanson L. Reuteri PlusLactobacillus reuteri, Lactobacillus rhamnosus, Lactobacillus acidophilus7 billion1 capsule per day

How many CFUs should my probiotic have?

When searching for a probiotic product, you want to pay attention to both the strains and the number of colony-forming units (CFUs). CFUs are the measure of viable bacteria present in a probiotic supplement. Though the number of probiotic strains may be important, research suggests that the specific types included are often key to microbial balance.

When considering the amount of probiotic CFUs (colony-forming units) to buy, several factors should be taken into account. Firstly, you should consider your individual health needs. Depending on what condition or symptoms you are looking to treat, the number of probiotics required may vary. For example, if it is for general gut health maintenance, then a lower dose of 5-10 billion CFU daily may be enough. However, if you’re looking to treat a specific condition such as IBS or SIBO, then higher doses of up to 50 billion CFU or even more may be needed to achieve desired results. If you have Candida Overgrowth, it’s best to start slowly by choosing a probiotic with fewer CFUs. This will help avoid shocking your system. After you’re more comfortable and the die-off symptoms have dissipated, you may want to change to a probiotic containing a higher number of CFUs.

You should also factor in the strength of the product when deciding how many probiotic CFUs to buy. While a product may advertise a certain number of CFUs, it is important to know that some probiotics are stronger than others and may require lower doses for the same effect. It is recommended to speak to your healthcare provider about which probiotic strain or combination works best for you and how many CFUs you should take based on those factors. Alternatively, you can do your own research to find which strains are best to target a specific disease and the corresponding dosage.

Which Probiotic Strains to Buy?

When selecting the right probiotic supplement, it is important to ensure that the bacteria strains are carefully chosen and specifically selected for their health benefits. There are a variety of bacterial species available, each with its own specific characteristics. For example, some bacterial species have been studied for their potential to reduce gut inflammation, while others may aid in reducing food allergies or provide relief from certain digestive conditions such as irritable bowel syndrome. If you want to target Candida Overgrowth and other gut symptoms you are experiencing at the same time, it is important to pick the right mix of bacteria strains.

In addition to considering which bacteria strains you want to include in your supplement regimen, it’s also important to consider how many different types of bacteria are present. A probiotic supplement that contains only one strain usually offers a more targeted approach, as it contains CFUs of just one species. On the other hand, multiple-strain products containing several different species can provide a broader range of health benefits but may have fewer CFUs per strain.

Finally, it is essential to look for products that are manufactured under high-quality standards and verified by third-party laboratories. This helps ensure that the product contains what is stated on the label and delivers maximum efficacy when taken as directed. The right choice in probiotics can make all the difference in achieving optimal gastrointestinal health and removal of Candida Overgrowth. Therefore, it is important to do your research and choose a product that contains the right strains of bacteria to get the most out of your supplement regimen.

Though an overwhelming number of probiotic strains exist, these are the most commonly used families of probiotic strains:


Lactobacilli are a type of bacteria that mainly breaks down carbohydrates to produce lactic acid. It’s a broad family of bacteria that includes 80 different types of Lactobacilli strains so far.

Lactobacilli are essential for the making of foods that need lactic acid fermentation, such as yogurt, cheese, sauerkraut, pickles, and other fermented products.

Lactobacilli and Bifidobacterium are the first types of bacteria to enter and establish themselves in the gut of an infant after delivery. It’s normally present in both the vagina and gastrointestinal tract.

Lactobacilli is a popular probiotic because of its many advantages, including tolerance to stomach acid and bile, ability to stick to intestinal surfaces and withstand low pH and gastric juice. This means that this type of probiotic is more likely than others to make it through the digestive system unchanged and be able to colonize the gut flora.

Many studies suggest that Lactobacilli strains help reduce the chance of diarrhea caused by taking antibiotics. Lactobacilli not only help remove cholesterol but also hinder pathogenic species, acting as antimicrobials. Lactobacillus rhamnosus has been shown to be effective in clearing respiratory viruses. A published meta-analysis showed that Lactobacillus strains were effective in preventing recurrent urinary tract infections in adult women.

It’s important to keep in mind that it takes a while to build up Lactobacilli levels in the gut, and they quickly disappear once supplementation stops. Thus, Lactobacilli require longer intake of supplementation for it to be more effective.


Bifidobacterium is an anaerobic bacteria, meaning it doesn’t require oxygen to live. It helps the gut break down food and produce lactic and acetic acid.

This bacteria is one of the first to colonize an infant’s intestinal tract while they are born. The Bifidobacterium infantis bacteria are uniquely adapted to the gut of an infant because they can feed off complex carbohydrates found in human milk. Bifidobacteria are essential from the time we’re born and into adulthood. They make up a large portion of the beneficial bacteria in our gastrointestinal tract that help us stay healthy.

Bifidobacterium infantis has been shown to be particularly effective in improving gastrointestinal health. This strain can help reduce inflammation and gut permeability, including the cases of “leaky gut”, by producing short-chain fatty acids when fermenting dietary fibers.

Various types of diarrhea can also be treated by Bifidobacterium infantis. Studies have shown that this strain is effective in reducing the duration of acute diarrhea. It also helps to prevent antibiotic-associated diarrhea and traveler’s diarrhea.

Bifidobacterium animalis-containing fermented milk products have been reported to help with regularity and prevent constipation.


Saccharomyces is a group of fungi that contains many species of yeasts. The word Saccharomyces comes from the Greek language and it means sugar fungus.

It is also called brewer’s yeast or baker’s yeast. For example, Saccharomyces cerevisiae is essential in the production of bread. Similarly, Saccharomyces bayanus is used to make wine and Saccharomyces boulardii is often used in medicine.

Several clinical trials strongly suggest that Saccharomyces boulardii can be used for the prevention and treatment of several gastrointestinal diseases. This strain produces responses that protect the gut in a way similar to healthy gut flora.

Saccharomyces boulardii is a probiotic with many health benefits, including preventing the growth of parasites and bacteria. It also inhibits pathogenic bacteria from adhering to cells. S. boulardii also acts as an antitoxin against various pathogens, including E. coli and cholera.

Saccharomyces boulardii has been proven to be effective against several acute and chronic diseases. This strain helps to lessen diarrhea symptoms and duration, regardless of the cause. It’s effective against chronic diseases, such as Crohn’s disease, ulcerative colitis, and irritable bowel syndrome (IBS).

S. boulardii should be cautiously considered for immunocompromised patients or individuals in hospitals because it could cause fungemia or localized infections..

Note that some S.boulardii probiotics are not shelf stable and require refrigeration. Furthermore, heat and sun exposure can reduce their efficacy.


Lactococcus is a group of bacteria that were formally classified under the genus Streptococcus Group. The only product these bacteria produce is lactic acid through the process of glucose fermentation.

Lactococcus lactis has a rich history of being used in the fermentation process of numerous food items, such as cheese and yogurt. Because it is such a common ingredient with a long-standing tradition, the FDA has categorized it as GRAS (generally recognized as safe). L. lactis not only provides flavor but also creates Nisin, a peptide that acts as a preservative in food.

Lactococcus lactis is commonly used to deliver therapeutics because it does not colonize the gut and can survive passage through the gastrointestinal tract. This strain can deliver cytokines into the body. Cytokines are molecules that send messages between cells. When released, they signal the immune system to do its job by stimulating the immune system or slowing it down.

Lactococcus lactis strains have also been looked into as a possible remedy for food allergies, such as cow’s milk allergy. In an animal study, it was shown that the allergen caused less sensitivity and built higher tolerance towards the allergen.

In combination with other probiotics, Lactococcus lactis is also used to treat antibiotic-associated diarrhea.

In addition to supporting digestive health, probiotic strains of Lactococcus may also help improve skin health. Studies have suggested that these bacteria can improve skin hydration and reduce acne breakouts.

“Probiotic cocktails”

Multiple probiotic strains working together have been more successful in treating certain diseases. Here are a few examples:

  • Travelers’ diarrhea

The most commonly used probiotics are Lactobacillus acidophilus, Lactobacillus rhamnosus, Saccharomyces boulardii, Bifidobacterium bifidum, and Bacillus coagulans

  • Bacterial vaginosis

Promising results have been seen in treating bacterial vaginosis by using Lactobacilli strains together with antibiotics.

  • Constipation

The review of randomized trials revealed that Bifidobacterium lactis and Lactobacillus casei were effective in the treatment of functional constipation for adults.

  • Ulcerative colitis

In a study, patients with ulcerative colitis took a probiotic that included three Bifidobacterium strains, four Lactobacillus strains, and one S. thermophilus strain. The results showed that fifteen out of the twenty patients remained in remission throughout the trial, meaning that taking this probiotic helps prevent relapse for those suffering from ulcerative colitis.

When Should I Take Probiotics?

Probiotics are most effective when taken 30 minutes before breakfast or right before bedtime. You’ll reap the most probiotic benefits when you take them on an empty stomach. That’s because stomach acid breaks down food as it enters your small intestine, and these supplements are no exception. Your stomach contains enzymes that protect your body against harmful bacteria and viruses. This is bad news for the probiotic bacteria, as prolonged exposure to stomach acid kills them. Our objective is to ensure the probiotics pass through your stomach acid quickly.

Everything you eat and drink causes the stomach to secrete stomach acid and digestive enzymes. The more you eat, the heavier your meal will be, and the higher your level of stomach acid production will be. This means that food spends more time in your stomach before moving to your small intestine. On average, the stomach takes 4-5 hours to digest food. If you take a probiotic after consuming a large meal, the probiotic will have to endure the stomach’s acidity for much longer before it can reach the small intestine.

Some probiotic strains are more susceptible to stomach acid than others. For example, Saccharomyces boulardii microorganisms survive in equal numbers whether taken on an empty stomach or with a meal (2). On the other hand, Lactobacillus and Bifidobacterium survive best when taken up to 30 minutes before a meal.

Generally, taking probiotics at least 30 minutes before a meal or 2-3 hours after a meal will reduce the time it takes for the good bacteria to get to your gut.

Though some may debate whether it is more important to take probiotics with or without food, consistency is probably the key factor.

Another thing to keep in mind is that you can optimize the effects of probiotics by taking them with specific foods. According to research, taking most kind of probiotics with some healthy fats in your meal may improve the survival rate of good bacteria in your digestive tract. However, Lactobacillus probiotics are more likely to survive when consumed with carbs, as they use glucose for energy in an acidic environment (3).

If you want to maximize the effectiveness of your probiotics, try taking them at night right before going to sleep or first thing in the morning before your breakfast.

How Long Should I Take Probiotics?

It is important to understand that the length of time you need to take probiotics will vary depending on your individual health needs. Generally, probiotics should be taken for at least a few weeks, but the amount of time can range from several days up to several months or even years.

There have been studies showing that a short-term intake (one week) of probiotics is insufficient to colonize the gut with “good bacteria.” The benefits of taking commercial probiotics ceased a few days after the supplementation is stopped (4).

For example, if you are taking probiotics with antibiotics to improve your gut health and don’t have any other underlying health conditions, you might only need to take them for as long as the antibiotic course. To effectively fight Candida Overgrowth, you will need to take probiotics for at least a few weeks – the duration of the Candida Meal Plan. You should continue consuming probiotics even after you’re done with the Candida Meal Plan and have started eating a greater variety of foods to keep up the results you’ve achieved. This latest study has shown that the probiotic strains from supplements are no longer detectable after 4 weeks of stopping supplementation (5).

It’s also important to remember that everyone’s body responds differently to probiotics and that some people may need to take them for longer than others. The degree to which someone suffers from Candida Yeast Overgrowth varies. If you have been experiencing symptoms for a long time or have chronic Candida Overgrowth, it would be beneficial to take probiotics for extended periods of time, much longer than the duration of the Candida Meal Plan.

It is also important to remember that probiotics are not one-size-fits-all solutions, and it is important to take note of how you feel while taking them. If no improvement is seen after 4 weeks or you experience side effects, the dosage may need to be adjusted or alternative probiotics may need to be tried.

Antifungal Supplements for Candida

Candida is an opportunistic pathogen that can cause serious health problems when it is allowed to grow and spread unchecked in our bodies. Additionally, Candida albicans (C. albicans) create biofilms around their colonies, which protect them from the body’s immune system and make Candida infections difficult to treat.

Antifungals work by either killing the Candida Yeast directly or preventing it from replicating. Some antifungals attack the biofilm itself making Candida Yeast cells more vulnerable and susceptible to the treatment.

The best way to treat Candida Overgrowth is by following an anti-inflammatory and low-sugar Candida diet, as well as taking probiotics and antifungals.

Though pharmaceutical antifungal drugs, such as fluconazole and nystatin, are effective against fungus growth, they may also cause serious side effects. These prescription antifungals should only be used under close medical supervision to avoid developing Candida’s resistance to the medication. Alternatively, you can find natural antifungal foods, as well as take antifungal supplements against Candida infections. The effectiveness of antifungal compounds and natural antifungal herbs varies according to the strain of Candida and your personal supplement compatibility, but some natural antifungal supplements have proven to be effective against a wide range of fungi.

The Benefits of Taking Antifungal Candida Supplements

There are several benefits to taking antifungal Candida supplements, including:


Antifungal supplements are not only easy to take but they can also be taken at any time without worrying about meal planning or preparation. Some antifungal supplements come in a capsule form, while others are liquid extracts.


The supplement enables you to manage the dosage and concentration of a specific antifungal ingredient. If you are taking multiple antifungal supplements, being able to control the dosage is key.

Complementary to antifungal foods

Even though antifungal foods are the most natural method to consume antifungals, it is tough to determine precisely how active the compound you are receiving. Antifungal supplements will make up for the dosage you’re missing from food. When you opt for supplements, you also have a wider array of options to choose from than if you were getting your nutrients solely from food. Not to mention, you can rotate your antifungal supplements to avoid antifungal resistance.

Supplements List for Fungal Infections

1. Caprylic Acid

Caprylic acid, which is found in coconut oil, is an effective antifungal agent. It works by disrupting the cell membranes of Candida fungi and preventing Candida Yeast overgrowth and reproduction.

Related studies show that Caprylic acid, taken orally, might be more effective in the fight against Candida albicans than fluconazole–a commonly prescribed antifungal medication (1).

Not only is it effective when used internally, but it can also be applied topically to help treat skin infections thanks to its antimicrobial properties.

Caprylic acid is also beneficial in helping to regulate blood sugar levels, as well as cholesterol. It can help reduce the risk of diabetes and heart disease by improving the way your body metabolizes glucose. Furthermore, Caprylic acid can help with digestion by aiding in the breakdown of fats and proteins.

2. Silymarin

Silymarin, a flavonoid derived from the milk thistle plant (Silybum marianum), has been used medicinally for thousands of years. Traditionally, it was used to treat liver and gallbladder problems, but in recent years, research has continued to show that Silymarin is also highly effective against several fungal infections.

Studies have shown that Silymarin inhibits the growth and spread of Candida cells. This makes it difficult for the fungus to survive in a host. In fact, the study has shown that Silymarin provides antifungal activity against Candida albicans, C. glabrataC. parapsilosis, C. tropicalis, and C. krusei strains. Furthermore, Silymarin can be taken together with prescription antifungal drugs as there are no negative interactions between the two (2).

3. Berberine

Berberine is a bioactive compound that can be extracted from several different plants, including Goldenseal (Hydrastis Canadensis) and Barberry (Berberis Vulgaris). Berberine is a powerful alkaloid with active compounds that can be used to develop new drugs. Alkaloids have a variety of physiological effects, such as antibacterial, anti-inflammatory, analgesic, psychotropic, and anti-tumor activity.

Though it is commonly used to help regulate blood sugar and weight, thereby reducing the likelihood of developing heart disease, there have been studies that suggest Berberine may also be effective treating Candida infections. One study found that Berberine might reduce the strength of biofilms created by fluconazole-resistant Candida tropicalis cells in a laboratory setting (petri dish experiments, as opposed to animal studies) (3). The exact mechanism of action is not yet known, but it likely involves disruption of membrane permeability or cell wall integrity.

Berberine has also been shown to possess significant antioxidant properties which could help protect against oxidative damage caused by fungal form infections (4).

4. Oregano Oil

Oregano oil is derived from the herb Oregano (Origanum vulgare), native to the Mediterranean. Oregano herb has been used since ancient times as a culinary and medicinal herb. Oregano oil is a concentrated extract of the Oregano herb, made by steam-distilling the leaves and flowers of the plant. This is different from the essential oil of oregano, which should not be consumed.

Oregano oil has long been used in traditional medicine for its potent antifungal properties and as a natural antibiotic. It contains Thymol and Carvacrol, two compounds that treat fungal infection and Candida biofilms (5). Another study revealed that Oregano oil is effective at inhibiting some Candida species, which provides an opportunity to use it alongside the prescription antifungals and reduce their dosage (6).

In addition to its antifungal properties, Oregano leaf extract may also provide additional benefits when used to treat Candida Yeast Overgrowth. This includes stimulating the immune system, reducing inflammation, and improving digestion.

If you decide to take Oregano oil in liquid form, make sure that it is mixed with carrier oil like olive or coconut oil. Oregano oil has a strong and spicy taste that can be difficult to stomach without the addition of carrier oil.

5. NAC

NAC (N-acetylcysteine) is a supplement form of Cysteine. Cysteine is found in most protein-rich foods, such as meats, seafood, and dairy products. It’s considered a semi-essential amino acid as your body can produce it from other amino acids.

NAC is primarily used as an antioxidant because it helps neutralize free radicals, which are molecules that can damage cells and tissue in your body. It is also routinely used as an antidote to acetaminophen (Tylenol) overdose because it helps prevent liver damage caused by the medication.

Recent research has found NAC can prevent Candida biofilm formation, a process the fungus uses to protect itself from antifungal medications and the body’s immune response (7).

NAC aids in proper liver function, assisting your body to process and expel toxins produced by Candida Overgrowth. This helps reduce uncomfortable symptoms associated with Candida Yeast Overgrowth.

NAC can be taken orally in capsule form or powder mixed into water.

6. Echinacea

Echinacea (E. purpurea)or purple coneflower is one of the most popular herbs worldwide. Native to North America, Echinacea is an herb commonly used to treat colds and flu.

Echinacea plants contain an impressive variety of active compounds, such as caffeic acid, alkamides, phenolic acids, rosmarinic acid, polyacetylenes, and many more. These compounds act as antioxidants and are responsible for the medicinal properties of Echinacea.

Polysaccharides, one of the main active compounds, help to inhibit the growth of Candida albicans, making it a great natural remedy for fighting off Candidiasis (8).

In addition, Echinacea acts as an immune stimulant and helps to strengthen the body’s defenses against Candida infection. Studies have shown that Echinacea increases the production of white blood cells, which are essential for fighting off infection (9).

It is typically taken in capsule or tincture formEchinacea tea is also widely available. For an immunity boost, drink two cups a day.

7. Garlic Extract

Garlic extract has been proven to be a powerful antifungal agent against Candida albicans, the most common cause of yeast infections.

Allicin and Ajoene are the two active ingredients in garlic extract known for their antibacterial and antifungal properties. Allicin works by inhibiting the growth of fungi on the skin and mucous membranes, while Ajoene blocks the biofilm formation of Candida Yeast infections and other pathogens (10).

Consuming fresh garlic is the best way to receive all of its antifungal properties, but some people cannot tolerate it well. If you have to interact with colleagues face-to-face at work, eating fresh garlic is out of the question because it causes bad breath. If you’re worried about garlic’s strong smell, there are multiple dietary supplements that allow you to get the benefits of garlic without causing bad breath.

Aged garlic extract and fermented garlic are better than raw garlic at providing antioxidant and antiglycation (anti-aging) benefits (11). If you can find them, aged garlic supplements are gentler on the stomach compared to other versions of garlic.

8. Pau D’Arco

Pau D’Arco (Tabebuia impetiginosa and Tabebuia avellanedae species) is a bark of a tree that has been used by native people of the Amazon to treat a variety of conditions, including fungal infections and inflammation.

The bark of the Tabebuia tree has properties that make it resistant to rotting, mold, and other common tree pathogens. The two main active compounds in the plant, Lapachol and Quercetin, are thought to be responsible for the medicinal benefits.

Several studies conducted using test tubes found that Lapachol was able to eliminate various disease-causing bacteria in the gut as well as viruses linked to common cold and flu symptoms (12).

Although animal studies show promise, there is still a lack of human trials. Furthermore, the doses that showed positive effects in the studies would be toxic to humans. Pau D’Arco supplements usually come in 500- to 550-milligram capsules. Because it’s difficult to control dosage when taking Pau D’Arco in its raw form as bark tea, it’s best to be extra cautious with this type of supplementation.

9. Olive Leaf Extract

Olive leaf extract (OLE) is made from the leaves of the olive tree and contains phytonutrients and antioxidants. The main three phenolic compounds present in olive oil – oleuropein, hydroxytyrosol, and tyrosol, are responsible for the antioxidant properties. The concentration of these compounds is significantly higher in OLE than in extra virgin olive oil.

A study conducted on olive leaf extract against the presence of Candida showed that it was able to effectively suppress the fungus. The study showed that Olive leaf extract is effective in the treatment and prevention of Candidiasis and oral thrush caused by Candida albicans (13).

Not only does Olive leaf extract help cure Candida infection, but it also helps improve heart health and reduce inflammation. Olive leaf extract has been found to help reduce LDL (bad) cholesterol levels and increase HDL cholesterol levels in people with high cholesterol.

Taking a supplement like OLE is a great way to get the health benefits of olive oil, even if you don’t cook with it.

10. Ginger

Though most people associate Ginger with green tea, you would have to eat a lot of it to get an adequate amount of ginger. If you don’t eat much Ginger or find it hard to work into your dishes, ginger supplements may be the way to go in order to ensure you’re getting enough.

The natural antifungal properties of Ginger come from the antioxidant compounds – gingerols, shogaols, and paradols.

Several studies have shown Ginger’s effectiveness against Candida fungal cells. One study found that a mouthwash containing ginger extract was an effective natural antifungal compound against Candida albicans and Candida Krusei, as well as preventing biofilm buildup (14). In a study published in the American Journal of Applied Sciences, researchers discovered that Ginger is comparable in effectiveness to Nystatin, a prescription drug, in fighting off Candida (15). A study published in 2021 showed that using Ginger extract alongside Fluconazole is more effective in treating drug-resistant vulvovaginal candidiasis (16).

11. Turmeric

Turmeric is the spice that gives curry its yellow color. Curcumin, a polyphenolic compound in turmeric with antimicrobial properties, is what gives turmeric its color. The actual turmeric spice only contains around 3% of curcumin by weight. You would need to consume large quantities of turmeric with your food to get the dosages used in the studies showing the effectiveness of curcumin against Candida. The right dosage of the active ingredient is easily attained through a supplement that also contains Piperine to amplify the absorption of Curcumin.

Curcumin has been shown to be effective against Candida in multiple studies over the years, but one study stands out because it tested Curcumin’s efficacy against 23 different strains of fungi. The study found that Curcumin is a powerful antifungal, more potent than Fluconazole against certain strains of fungi (17).

According to another study, Curcumin’s effectiveness against candida increases 10-fold when taken together with ascorbic acid (vitamin C) (18).

Unlike other supplements, Curcumin is fat-soluble, meaning it breaks down and dissolves in fat or oil. For optimal absorption of the turmeric supplement, consider taking it with a meal that contains high levels of fat.

When Should I Take Antifungals for Candida infections?

The timing of when you take antifungals is crucial. Here are some general tips:

Start slow

The Candida Meal Plan is the best place to start when you are trying to fight Candida Overgrowth because three factors are in play – dietary changes, taking probiotics, and antifungals. After 2-3 weeks of following an anti-inflammatory, low-sugar Candida diet, you may want to consider adding probiotics to your routine. After you begin taking probiotic supplements and consuming probiotic foods, it is best to wait a week before introducing antifungals. If you begin taking antifungals while in the initial phase of starting the Candida Meal Plan, they won’t be as beneficial because they will likely be cleared out by your system along with all the pathogens. Starting the Candida Meal Plan alone will likely cause the Candida die-off process. Candida is destroyed by both probiotics and antifungals. Starting antifungals and probiotics at the same time can lead to releasing toxins into your digestive tract because it kills Candida Yeast cells too rapidly. The Candida die-off process, also known as the Herxheimer reaction, can cause many uncomfortable Candida symptoms in addition to those caused by intestinal Candida Overgrowth.

It’s essential to allow adequate time for each step so that you can comfortably make the necessary changes and enjoy the process overall.

Take several antifungals consistently

For the best results possible, try taking at least two antifungals consistently at the same time. You need to be consistent with your treatment to prevent Candida albicans from adapting to the treatment. If you rotate antifungals before they have had a chance to work, Candida can build up resistance against them. It is more effective to use a set of antifungals and give them time to work their magic, rather than rotating them too quickly.

Take antifungals with probiotics

The Candida Meal Plan is designed to help eliminate Candida overgrowth by cutting off its food sources and destroying the yeast cells.

Antifungals and probiotics are both important in the fight against Candida Overgrowth, and they actually work together to provide effective treatment. Antifungals work by weakening the Candida biofilm and destroying its colonies. Then, probiotics replenish your gut with good bacteria to prevent Candida yeast cells from overgrowing again.

In a 2017 study, antifungals and probiotics were shown to be effective treatments for inflammatory bowel diseases. Antifungals and probiotics are very effective when used together because the former works to break down biofilms while the latter reestablishes gut flora (19).

Take antifungals at different times of day

To see the best results, it’s recommended that you take probiotics and antifungals at different times during the day. By doing this, you stop the mild antibiotic properties in your antifungals from interfering with your probiotics. Most probiotic bacteria strains, except for Saccharomyces boulardi, are very susceptible to antibiotics. So it’s important to take antifungals separately from probiotics.

Take antifungals after meals

Antifungal medication is more likely to be effective when taken with a meal or snack, to reduce the chances of upsetting the stomach. Also, eating meals stimulates digestion and provides a greater opportunity to properly absorb antifungals.

As a general guideline, it is best to wait at least an hour or two between taking your probiotics and antifungals. For example, you can take probiotics early in the morning before breakfast and take your antifungals with lunch or dinner.

How Long Should I Take Antifungals for Candida Overgrowth?

Antifungals, in contrast to probiotics, should be thought of as medication with a set length of treatment. You can discontinue taking your antifungals once you’ve completed your treatment plan and feel that you have overcome your Candida Yeast Overgrowth. Although it’s usually good to take probiotics for extended periods of time to maintain your healthy gut flora, taking antifungals for too long may have the opposite effect. Antifungals are natural antibiotics and can kill off healthy bacteria in your intestinal tract if used too long. Plus, Candida can become resistant to antifungals if you take them too long.

When you decide to stop taking antifungals, start tapering off both the dosage and frequency. Keep an eye out for any return of Candida Overgrowth symptoms. If you feel that your Candida Overgrowth symptoms are coming back, return to your original dosage until the Candida symptoms resolve. If you’re feeling okay after cutting back on your antifungals, then go ahead and keep reducing your intake until you don’t need the supplements anymore. If you have any questions or concerns about how to treat fungal infections, speak to your doctor about your possible options for antifungal Candida treatment.

Digestive Enzymes for Candida

Healthy gut flora is essential for a properly functioning digestive system. The right kinds and levels of digestive enzymes help break down food into molecules that can be absorbed, making digestion more efficient. When you have a sufficient amount of enzymes in your digestive system, it runs more smoothly. A healthy digestive system discourages the growth of Candida and other harmful bacteria by maintaining a low pH level in your stomach.

If you suspect Candida Overgrowth, you are likely experiencing indigestion and related symptoms, such as gas, bloating, and heartburn. This may be a sign that your digestive system is not as efficient in breaking down foods as it should be, or that you have an inadequate amount of digestive enzymes. When Candida Overgrowth occurs, it prevents the body from being able to absorb essential vitamins and nutrients. Digestive enzymes can help break down the food you eat, so your body can properly absorb the vitamins and minerals.

The importance of digestive enzymes for proper metabolic function cannot be overstated. When used in conjunction with the Candida Meal Plan, they can have a powerful effect on your health by supporting your digestion and helping to keep Candida in check.

It is believed that digestive enzymes can also assist in breaking down Candida cell walls and their biofilms, making them unable to function. For example, the enzyme Cellulase is thought to be effective in breaking down Candida cell walls, and Protease specifically eliminates protein waste inside fungal cells (1).

Types of Digestive Enzymes

There are 3 main groups of digestive enzymes:


Amylase breaks down carbohydrates into simpler sugars such as glucose. These simple sugars can be used for energy more easily by the body. If you do not have enough amylase, it can result in diarrhea (2).


Protease is an enzyme that helps break down proteins into smaller polypeptides and amino acids, which the human body can use. The production of protease decreases with age. When there is a lack of protease, it can result in allergies or toxicity in the intestines.


These enzymes break down animal fats and oils into fatty acids and glycerol, which aids in the absorption of these nutrients.  Fatty acids make up the cell membranes and provide energy, among other things.  If you don’t have enough lipase, you won’t be able to absorb fat-soluble vitamins like A, D, E and K (3).

Digestive Enzymes List

BrandTypes of enzymesPurpose
Best Naturals Natural Lactase EnzymeLactase Enzyme 3,000 FCC ALUTo breakdown Dairy
Doctor’s Best Digestive EnzymesAmylase Blend 20,000 DU, Protease SP Plus Blend 95,000 HUT, Dipeptidyl-peptidase lV 250 DPP-lV, Bromelain 50 GDU, Papain 500,000 FCC PU, Invertase 100 lNVU, Cellulase 3250 CU, Beta-glucanase 65 BGU, Alpha-galactosidase 500 GalU, Hemicellulase 750 HCU, Xylanase 650 XU, Phytase 10 FTU, Glucoamylase 50 AGU, Lipase 3000 FIP, Lactase 1000 ALU, Bacillus subtilis 1 Billion CFUMulti-purpose
Enzymedica CandidaseCellulase Thera-blend 60,000 CU, Protease Thera-blend 230,000 HUTTo breakdown Fiber and Proteins
Integrative Therapeutics Lipase Concentrate-HPMicrobial Enzymes 110 mg, Lipase I, II 12,600 FIP/5,160 LUTo breakdown Fats
Naturenetics DigestWise Powerful Digestive EnzymesTo breakdown Protein: Protease 40,000 HUT, Acid Stable Protease 500 HUT To breakdown Fats: Lipase 1,000 FIP To breakdown Carbohydrates: Amylase 10,000 SKB, Alpha-Galactosidase 165 GAL, Pectinase 55 Endo PG To breakdown Dairy: Lactase 250 ALU To breakdown Sugars: Amyloglucosidase 10 AG To breakdown Fiber: Cellulase 2,000 CU, Hemicellulase 450 HU FCCMulti-purpose
NOW Supplements  Pancreatin 2000Pancreatin 2000 mg, Amylase 50,000 USP units, Protease 50,000 USP units, Lipase 4,000 USP unitsMulti-Purpose
NOW Supplements Optimal Digestive System Full Spectrum EnzymesAmylase Blend 20,000 DU, Protease SP Plus Blend 95,000 HUT, Dipeptidyl-peptidase lV 250 DPP-lV, Bromelain 50 GDU, Papain 500,000 FCC PU, Invertase 100 lNVU, Cellulase 3250 CU, Beta-glucanase 65 BGU, Alpha-galactosidase 500 GalU, Hemicellulase 750 HCU, Xylanase 650 XU, Phytase 10 FTU, Glucoamylase 50 AGU, Lipase 3000 FIP, Lactase 1000 ALU, Bacillus subtilis 1 Billion CFUMulti-purpose
Transformation Protease Enzyme Supplement Tzyme Protease Blend (peptidases, bromelain) 600,000 PU  (492 mg equivalent)To breakdown Proteins

When Should I take Digestive Enzymes?

You should always consult the directions on the bottle of digestive enzyme that you are taking. In most cases, you’ll experience the best results if you take digestive enzyme supplements right before eating. The enzymes should have enough time to reach your stomach and mix with the gastric juices. If you’d rather, taking digestive enzymes as soon as you start eating should work just as well. If you take digestive enzymes after eating, they will be less effective as the food has already started digesting in your stomach.

You should also take different types of enzymes in combination with the foods they work well with. For example, Protease supplements help break down animal proteins. To get the most benefit from them, take them along with meals that have meat.

Also, check the proper dosage, which will vary based on the type and strength of the enzyme supplement.

While some people argue over whether or not digestive enzymes and probiotics should be taken together or separately, it’s important to note that probiotics themselves produce digestive enzymes (4). If enzymes destroyed probiotics, probiotics wouldn’t be able to survive in the gastrointestinal tract. Therefore, it is possible to take probiotics together with digestive enzymes.